Rat IP 10 Recombinant Protein (RPPB1173)
- SKU:
- RPPB1173
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- P48973
- Research Area:
- Chemokines
Description
| Product Name: | Rat IP 10 Recombinant Protein |
| Product Code: | RPPB1173 |
| Size: | 25µg |
| Species: | Rat |
| Target: | IP 10 |
| Synonyms: | C-X-C motif chemokine 10, Gamma-IP10, IP-10, Protein Mob-1, Small-inducible cytokine B10, Cxcl10, Inp10, Mob1, Scyb10. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized IP-10 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IP-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP |
| Biological Activity: | Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 10.0-50.0 ng/ml. |
Chemokine (C-X-C motif) ligand 10 (CXCL10) is a small cytokine belonging to the CXC chemokine family. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes and T cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.
IP-10 Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.6kDa.The IP-10 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development. |
| NCBI Summary: | induces DNA synthesis, cell proliferation, and cell migration in vascular smooth muscle cells; may play a role in vascular remodeling [RGD, Feb 2006] |
| UniProt Code: | P48973 |
| NCBI GenInfo Identifier: | 146345511 |
| NCBI Gene ID: | 245920 |
| NCBI Accession: | P48973.2 |
| UniProt Secondary Accession: | P48973,P70538, Q6GTC7, |
| UniProt Related Accession: | P48973 |
| Molecular Weight: | 10,729 Da |
| NCBI Full Name: | C-X-C motif chemokine 10 |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 10 |
| NCBI Official Symbol: | Cxcl10�� |
| NCBI Official Synonym Symbols: | IP-10; Scyb10�� |
| NCBI Protein Information: | C-X-C motif chemokine 10; gamma-IP10; protein Mob-1; small-inducible cytokine B10; interferon-inducible protein 10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily (Cys-X-Cys) member 10; small inducible cytokine B subfamily (Cys-X-Cys), member 10 |
| UniProt Protein Name: | C-X-C motif chemokine 10 |
| UniProt Synonym Protein Names: | 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Interferon-inducible protein 10; Protein Mob-1; Small-inducible cytokine B10 |
| UniProt Gene Name: | Cxcl10�� |
| UniProt Entry Name: | CXL10_RAT |
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