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Rat ENA 78 Recombinant Protein (RPPB1121)

SKU:
RPPB1121
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P97885
Research Area:
Chemokines
$371
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Description

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Product Name:Rat ENA 78 Recombinant Protein
Product Code:RPPB1121
Size:20µg
Species:Rat
Target:ENA 78
Synonyms:C-X-C motif chemokine 5, Small-inducible cytokine B5, Cytokine LIX, Cxcl5, Scyb5, LIX, GCP-2, Scyb6, ENA-78, AMCF-II.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2�m filtered concentrated (1.0mg/ml) solution in 1�PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized ENA-78 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized ENA-78 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:APFSAMVATE LRCVCLTLAP RINPKMIANL EVIPAGPHCP KVEVIAKLKN QKDNVCLDPQ APLIKKVIQK ILGSENKKTK RNALALVRSA STQ
Biological Activity:Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/ml.

Chemokine (C-X-C motif) ligand 5 (CXCL5) is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. Expression of CXCL5 has also been observed in eosinophils. This chemokine stimulates the chemotaxis of neutrophils possesses angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2. The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes. CXCL5 has been implicated in connective tissue remodelling.

Epithelial Neutrophil-Activating Protein 78 Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 93 amino acids and having a molecular mass of 10.0kDa.The CXCL5 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CXCL6: Chemotactic for neutrophil granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Cellular Component: extracellular space

Molecular Function:chemokine activity; CXCR chemokine receptor binding

Biological Process: organ regeneration; neutrophil mediated immunity; cytokine production; positive regulation of JAK-STAT cascade; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; midbrain development; response to gamma radiation; immune response; inflammatory response; regulation of chemokine production; leukocyte homeostasis

NCBI Summary:mouse homolog is a member of the CXC chemokine family, is a neutrophil chemoattractant and is rapidly induced in response to muscle injury [RGD, Feb 2006]
UniProt Code:P97885
NCBI GenInfo Identifier:11559996
NCBI Gene ID:60665
NCBI Accession:NP_071550.1
UniProt Related Accession:P97885
Molecular Weight:11.0 kDa
NCBI Full Name:C-X-C motif chemokine 5
NCBI Synonym Full Names:C-X-C motif chemokine ligand 6
NCBI Official Symbol:Cxcl6��
NCBI Official Synonym Symbols:Cxcl5��
NCBI Protein Information:C-X-C motif chemokine 5
UniProt Protein Name:C-X-C motif chemokine 5
UniProt Synonym Protein Names:Cytokine LIX; Small-inducible cytokine B5
UniProt Gene Name:Cxcl5��
UniProt Entry Name:CXCL5_RAT

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