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Rat CD48 monoclonal antibody (AGIM0284)

SKU:
AGIM0284
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Rat
Host Species:
Mouse
Isotype:
IgG1
Clone:
MRC OX-45
Conjugation:
Unconjugated
Applications:
FC
€179
Frequently bought together:

Description

system_update_altDatasheet
Product Name:Rat CD48 monoclonal antibody
Product Code:AGIM0284
Size:100 µg in 100 µL
Reactivity:Rat
Clone:MRC OX-45
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG1
Host Species:Mouse
Storage:For long term storage, aliquot and freeze unused portion at 20°C in volumes appropriatefor single usage. Avoid freeze/thaw cycles.
Uniprot:P08575
UniProt Protein Function:CD45: a receptor type protein tyrosine phosphatase protein. Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The first PTPAse domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Specifically expressed in hematopoietic cells. An essential regulator of T- and B-cell antigen receptor signaling. Functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. Suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine; EC 3.1.3.48; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q31-q32

Cellular Component: focal adhesion; membrane; integral to plasma membrane; plasma membrane; lipid raft; external side of plasma membrane

Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; protein kinase binding

Biological Process: B cell proliferation; axon guidance; substrate-bound cell migration, cell release from substrate; regulation of cell cycle; protein amino acid dephosphorylation; positive regulation of antigen receptor-mediated signaling pathway; T cell receptor signaling pathway; bone marrow development; B cell receptor signaling pathway; stem cell development; cell surface receptor linked signal transduction; dephosphorylation; positive regulation of protein kinase activity; release of sequestered calcium ion into cytosol; negative regulation of T cell mediated cytotoxicity; positive regulation of B cell proliferation; negative regulation of protein kinase activity; hemopoietic progenitor cell differentiation; negative regulation of cytokine and chemokine mediated signaling pathway; positive regulation of T cell proliferation; immunoglobulin biosynthetic process; defense response to virus; T cell differentiation

Disease: Hepatitis C Virus, Susceptibility To; Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-positive, Nk Cell-positive

NCBI Summary:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
UniProt Code:P08575
NCBI GenInfo Identifier:44242008
NCBI Gene ID:5788
NCBI Accession:AAS46946.1
UniProt Secondary Accession:P08575,Q16614, Q9H0Y6, A8K7W6,
UniProt Related Accession:P08575
Molecular Weight:61.6kD (predicted)
NCBI Full Name:CD45
NCBI Synonym Full Names:protein tyrosine phosphatase, receptor type, C
NCBI Official Symbol:PTPRC  
NCBI Official Synonym Symbols:LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180  
NCBI Protein Information:receptor-type tyrosine-protein phosphatase C; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide
UniProt Protein Name:Receptor-type tyrosine-protein phosphatase C
UniProt Synonym Protein Names:Leukocyte common antigen; L-CA; T200
Protein Family:Receptor-type tyrosine-protein phosphatase
UniProt Gene Name:PTPRC  
UniProt Entry Name:PTPRC_HUMAN

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