Rat BD 1 Recombinant Protein (RPPB0070)
- SKU:
- RPPB0070
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- O89117
- Research Area:
- Cytokines
Description
| Product Name: | Rat BD 1 Recombinant Protein |
| Product Code: | RPPB0070 |
| Size: | 20µg |
| Species: | Rat |
| Target: | BD 1 |
| Synonyms: | Beta-defensin 1, BD-1, rBD-1, Defensin beta 1, Defb1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | BD-1 protein was lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized BD-1 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized BD-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD-1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | DQYRCLQNGG FCLRSSCPSH TKLQGTCKPD KPNCCRS |
| Biological Activity: | Measured by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 ug/ml. |
The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis.Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. Beta Defensin is highly expressed by epithelial cells. Beta-defensin 1 may play a role in the pathogenesis of severe sepsis.
BD-1 Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 37 amino acids and having a molecular mass of 4.1kDa.The BD-1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | defensin, beta 1: Has bactericidal activity. Belongs to the beta-defensin family.Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 16q12.5Cellular Component: extracellular space; extrinsic component of membrane; intracellularMolecular Function: CCR6 chemokine receptor binding; identical protein bindingBiological Process: acute inflammatory response; antibacterial humoral response; cAMP-mediated signaling; defense response to bacterium; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; innate immune response; innate immune response in mucosa; response to bacterium; response to testosterone stimulus |
| UniProt Protein Details: | |
| NCBI Summary: | cationic peptides with broad-spectrum antimicrobial activity; may mediate mucosal defenses of several organs [RGD, Feb 2006] |
| UniProt Code: | O89117 |
| NCBI GenInfo Identifier: | 13929150 |
| NCBI Gene ID: | 83687 |
| NCBI Accession: | NP_113998.1 |
| UniProt Secondary Accession: | O89117 |
| UniProt Related Accession: | O89117 |
| Molecular Weight: | |
| NCBI Full Name: | beta-defensin 1 |
| NCBI Synonym Full Names: | defensin beta 1 |
| NCBI Official Symbol: | Defb1�� |
| NCBI Official Synonym Symbols: | CDK4�� |
| NCBI Protein Information: | beta-defensin 1 |
| UniProt Protein Name: | Beta-defensin 1 |
| UniProt Synonym Protein Names: | Defensin, beta 1 |
| Protein Family: | Beta-defensin |
| UniProt Gene Name: | Defb1�� |
| UniProt Entry Name: |
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