The RASSF7 Polyclonal Antibody (PACO16952) is a valuable tool for researchers studying RASSF7, a tumor suppressor gene involved in cell cycle regulation and apoptosis. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting RASSF7 in human samples, making it suitable for use in Western blot applications.RASSF7, a member of the Ras association domain family, acts as a mediator in signaling pathways that control cell growth and division. Dysregulation of RASSF7 has been linked to various cancers, highlighting its potential as a therapeutic target for cancer treatment.
By targeting RASSF7, researchers aim to understand its role in tumorigenesis and develop novel strategies for cancer therapy.The RASSF7 Polyclonal Antibody enables researchers to accurately detect and analyze RASSF7 expression in different cellular contexts, providing valuable insights into its function in cancer development and progression. Its reliability and specificity make it an essential tool for studies aiming to unravel the molecular mechanisms underlying tumorigenesis and identify potential targets for precision medicine approaches.
Gel: 8%SDS-PAGE, Lysate: 60 μg, Lane: Raji cells, Primary antibody: PACO16952(RASSF7 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16952(RASSF7 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200).
Background:
RASSF7 (Ras association domain-containing protein 7), also designated HRAS1-related cluster protein 1, is a 373 amino acid, protein that localizes to the centrosome. RASSF7, RASSF8, RASSF9 and RASSF10 are four evolutionary conserved proteins that are collectively known as the N-terminal RASSF family. Expressed in skin, neural tube and eye, RASSF7 is believed to play an essential role in mitosis. Further supporting its mitotic role, knockdown of Xenopus RASSF7 has been shown to influence cell failure to form mitotic spindle and also cause nuclear breakdown and apoptosis.
Synonyms:
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
UniProt Protein Function:
HRC1: 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 11p15.5Molecular Function: protein binding
