The RASSF3 Polyclonal Antibody (PAC016951) is specifically designed for research involving RASSF3, a protein known to play a role in cell cycle regulation and tumor suppression. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it a reliable tool for Western blot applications. By binding to the RASSF3 protein, this antibody facilitates the detection and analysis of RASSF3 in various cell types, making it ideal for studies in cancer biology and cell signaling pathways.
RASSF3, a member of the Ras association domain family, is known for its tumor-suppressive properties and ability to regulate cell proliferation and apoptosis. Its involvement in key cellular processes makes it a crucial target for research into cancer development and progression. By studying the functions of RASSF3, researchers can gain valuable insights into potential therapeutic strategies for combating cancer and understanding the underlying mechanisms of tumor growth.
Antibody Name:
RASSF3 Antibody (PACO16951)
Antibody SKU:
PACO16951
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human RASSF3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16951(RASSF3 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16951(RASSF3 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.
Synonyms:
Ras association (RalGDS/AF-6) domain family member 3
UniProt Protein Function:
RASSF3: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 12q14.2Cellular Component: cytoplasm; plasma membraneMolecular Function: identical protein binding; protein binding
UniProt Protein Details:
NCBI Summary:
The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003]
