The RASSF1 Polyclonal Antibody (CAB1203) is an essential tool for researchers studying the Ras association domain family 1 (RASSF1) protein, which is known for its tumor suppressor properties. This antibody, produced in rabbits, specifically targets human RASSF1 protein and has been validated for use in Western blot applications.RASSF1 is a key player in cell cycle regulation, apoptosis, and DNA repair processes, making it a critical molecule in cancer research. The RASSF1 Polyclonal Antibody enables the detection and analysis of RASSF1 protein expression in various cell types, providing valuable insights into its role in tumorigenesis and potential therapeutic applications.
With its high reactivity and specificity, the RASSF1 Polyclonal Antibody is a reliable tool for investigating the mechanisms underlying cancer development and progression. Researchers can use this antibody to explore the therapeutic potential of targeting RASSF1 in the treatment of various cancers, ultimately leading to advancements in cancer therapy and patient care.
Product Name:
RASSF1 Rabbit Polyclonal Antibody
SKU:
CAB1203
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 101-340 of human RASSF1 (NP_009113.3).
Cytoplasm, Nucleus, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle, spindle pole.
Calculated MW:
39kDa
Observed MW:
39kDa
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
11186
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using RASSF1 Rabbit pAb (CAB1203) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
