RASSF1 Rabbit Polyclonal Antibody (CAB1203)
- SKU:
- CAB1203
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | RASSF1 Rabbit Polyclonal Antibody |
SKU: | CAB1203 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 101-340 of human RASSF1 (NP_009113.3). |
Sequence: | CCGP RDLG WEPA VERD TNVD EPVE WETP DLSQ AEIE QKIK EYNA QINS NLFM SLNK DGSY TGFI KVQL KLVR PVSV PSSK KPPS LQDA RRGP GRGT SVRR RTSF YLPK DAVK HLHV LSRT RARE VIEA LLRK FLVV DDPR KFAL FERA ERHG QVYL RKLL DDEQ PLRL RLLA GPSD KALS FVLK ENDS GEVN WDAF SMPE LHNF LRIL QREE EEHL RQIL QKYS YCRQ KIQE ALHA CPLG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | 123F2; RDA32; NORE2A; RASSF1A; REH3P21; RASSF1 |
Positive Sample: | HeLa,HepG2,293T,SW480 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle, spindle pole. |
Calculated MW: | 39kDa |
Observed MW: | 39kDa |
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method: | Affinity purification |
Gene ID: | 11186 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |