RASGRF1 Rabbit Polyclonal Antibody (CAB6964)
- SKU:
- CAB6964
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | RASGRF1 Rabbit Polyclonal Antibody |
SKU: | CAB6964 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RASGRF1 (NP_001139120.1). |
Sequence: | MQKG IRLN DGHV ASLG LLAR KDGT RKGY LSKR SSDN TKWQ TKWF ALLQ NLLF YFES DSSS RPSG LYLL EGCV CDRA PSPK PALS AKEP LEKQ HYFT VNFS HENQ KALE LRTE DAKD CDEW VAAI AHAS YRTL ATEH EALM QKYL HLLQ IVET EKTV AKQL RQQI EDGE IEIE RLKA EITS LLKD NERI QS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1; RASGRF1 |
Positive Sample: | Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, growth cone, neuron projection, plasma membrane |
Calculated MW: | 145kDa |
Observed MW: | 145kDa |
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Purification Method: | Affinity purification |
Gene ID: | 5923 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |