The RASGEF1A Polyclonal Antibody (PACO16945) is a vital tool for researchers studying RASGEF1A, a protein involved in cell signaling pathways and implicated in various cellular processes. This antibody, generated in rabbits, demonstrates high specificity and sensitivity in detecting RASGEF1A in human samples, making it suitable for Western blotting experiments.RASGEF1A, also known as RasGEF domain family member 1A, plays a crucial role in regulating Ras signaling, which is involved in cell growth, differentiation, and survival. Dysregulation of Ras signaling has been linked to various diseases, including cancer and developmental disorders.
By targeting RASGEF1A with this antibody, researchers can gain insights into its function and potential implications in these pathological conditions.With its ability to detect RASGEF1A in different cell types, this antibody is valuable for studies in cell biology, molecular biology, and cancer research. By understanding the role of RASGEF1A, researchers can uncover novel therapeutic targets and develop interventions for diseases associated with aberrant Ras signaling pathways.
Antibody Name:
RASGEF1A Antibody (PACO16945)
Antibody SKU:
PACO16945
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human
Immunogen:
Fusion protein of human RASGEF1A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16945(RASGEF1A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
RASGEF1A (RasGEF domain family, member 1A) is a 481 amino acid, guanine-nucleotide exchange factor (GEF) for H-Ras, K-Ras, and N-Ras. RASGEF1A may also play a role in cell migration. RASFEG1A is highly expressed in spinal chord and brain and contains one N-terminal Ras-GEF domain and one Ras-GEF domain. The gene that encodes RASGEF1A maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome.
Synonyms:
RasGEF domain family, member 1A
UniProt Protein Function:
Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration.
