RASD2 Rabbit Polyclonal Antibody (CAB17367)
- SKU:
- CAB17367
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | RASD2 Rabbit Polyclonal Antibody |
SKU: | CAB17367 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 135-263 of human RASD2 (NP_055125.2). |
Sequence: | MVIC GNKN DHGE LCRQ VPTT EAEL LVSG DENC AYFE VSAK KNTN VDEM FYVL FSMA KLPH EMSP ALHR KISV QYGD AFHP RPFC MRRV KEMD AYGM VSPF ARRP SVNS DLKY IKAK VLRE GQAR ERDK C |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | Rhes; TEM2; RASD2 |
Positive Sample: | Mouse lung |
Cellular Localization: | plasma membrane, synapse |
Calculated MW: | 30kDa |
Observed MW: | 30kDa |
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients.
Purification Method: | Affinity purification |
Gene ID: | 23551 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |