The RASD2 Polyclonal Antibody (CAB17367) is a crucial tool for researchers studying RASD2, a GTPase activating protein involved in signal transduction pathways and neurological functions. This antibody, generated in rabbits, exhibits high specificity towards human samples and is validated for use in Western blot applications. By binding to RASD2 protein, the antibody enables precise detection and analysis in a variety of cell types, offering valuable insights into its role in neurological disorders and signaling pathways.
RASD2, also known as dexamethasone-induced Ras-related protein 2, is associated with dopamine signaling, neuronal plasticity, and synaptic transmission. Dysregulation of RASD2 has been linked to conditions such as addiction, schizophrenia, and Parkinson's disease, highlighting its importance in neurological research. By studying RASD2 with this antibody, researchers can further understand its functions and potential implications for therapeutic interventions in these debilitating conditions.
Product Name:
RASD2 Rabbit Polyclonal Antibody
SKU:
CAB17367
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 135-263 of human RASD2 (NP_055125.2).
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients.
Purification Method:
Affinity purification
Gene ID:
23551
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using RASD2 Rabbit pAb (CAB17367) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
