RASA3 Antibody (PACO20323)
- SKU:
- PACO20323
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
RASA3 Antibody (PACO20323)
The RASA3 Polyclonal Antibody (PAC020323) is a valuable tool for researchers studying RASA3, a protein involved in intracellular signaling pathways and cell cycle regulation. This antibody, produced in rabbits, has been shown to have high reactivity with human samples and is suitable for use in Western blot applications.RASA3, also known as Ras GTPase-activating protein 3, plays a crucial role in modulating Ras signaling pathways, which are involved in cell proliferation, differentiation, and survival. Dysregulation of Ras signaling has been implicated in various diseases, including cancer and developmental disorders.
By targeting RASA3, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.This antibody specifically binds to the RASA3 protein, allowing for its detection and quantification in various cell types and tissues. Its reliable performance and specificity make it an ideal tool for studies in cell biology, cancer research, and drug development. By understanding the function of RASA3, researchers can pave the way for novel approaches to treating Ras-related diseases and improving patient outcomes.
| Antibody Name: | RASA3 Antibody (PACO20323) |
| Antibody SKU: | PACO20323 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:30-1:150 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human RASA3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20323(RASA3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20323(RASA3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. |
| Synonyms: | RAS p21 protein activator 3 |
| UniProt Protein Function: | RASA3: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 13q34 Cellular Component: cytoplasm; cytosol Molecular Function:calcium-release channel activity Biological Process: MAPKKK cascade; negative regulation of Ras protein signal transduction; signal transduction |
| NCBI Summary: | This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q14644 |
| NCBI GenInfo Identifier: | 206729910 |
| NCBI Gene ID: | 22821 |
| NCBI Accession: | Q14644.3 |
| UniProt Secondary Accession: | Q14644,Q8IUY2, A6NL15, F8W6X8, |
| UniProt Related Accession: | Q14644 |
| Molecular Weight: | 92,228 Da |
| NCBI Full Name: | Ras GTPase-activating protein 3 |
| NCBI Synonym Full Names: | RAS p21 protein activator 3 |
| NCBI Official Symbol: | RASA3Â Â |
| NCBI Official Synonym Symbols: | GAPIII; GAP1IP4BPÂ Â |
| NCBI Protein Information: | ras GTPase-activating protein 3 |
| UniProt Protein Name: | Ras GTPase-activating protein 3 |
| UniProt Synonym Protein Names: | GAP1(IP4BP); Ins P4-binding protein |
| Protein Family: | Ras GTPase-activating protein |
| UniProt Gene Name: | RASA3Â Â |
| UniProt Entry Name: | RASA3_HUMAN |
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