RASA3 Antibody (PACO20322)
- SKU:
- PACO20322
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
RASA3 Antibody (PACO20322)
The RASA3 Polyclonal Antibody (PAC020322) is a versatile tool for research involving RASA3, a protein associated with cell signaling and regulation of immune responses. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the RASA3 protein, researchers can easily detect and analyze its expression in various cell types, making it an essential tool for studies in immunology and cancer research.RASA3 is a key player in cell signaling pathways and is involved in the regulation of immune responses.
Its role in immune system modulation makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of RASA3 is crucial for the development of new therapies that can modulate immune responses in these disease contexts.Overall, the RASA3 Polyclonal Antibody is a valuable resource for researchers looking to delve into the mechanisms of immune regulation and signal transduction pathways, with potential implications for the development of novel therapeutic strategies.
| Antibody Name: | RASA3 Antibody (PACO20322) |
| Antibody SKU: | PACO20322 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human RASA3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20322(RASA3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. |
| Synonyms: | RAS p21 protein activator 3 |
| UniProt Protein Function: | RASA3: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 13q34 Cellular Component: cytoplasm; cytosol Molecular Function:calcium-release channel activity Biological Process: MAPKKK cascade; negative regulation of Ras protein signal transduction; signal transduction |
| NCBI Summary: | This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q14644 |
| NCBI GenInfo Identifier: | 206729910 |
| NCBI Gene ID: | 22821 |
| NCBI Accession: | Q14644.3 |
| UniProt Secondary Accession: | Q14644,Q8IUY2, A6NL15, F8W6X8, |
| UniProt Related Accession: | Q14644 |
| Molecular Weight: | 92,228 Da |
| NCBI Full Name: | Ras GTPase-activating protein 3 |
| NCBI Synonym Full Names: | RAS p21 protein activator 3 |
| NCBI Official Symbol: | RASA3Â Â |
| NCBI Official Synonym Symbols: | GAPIII; GAP1IP4BPÂ Â |
| NCBI Protein Information: | ras GTPase-activating protein 3 |
| UniProt Protein Name: | Ras GTPase-activating protein 3 |
| UniProt Synonym Protein Names: | GAP1(IP4BP); Ins P4-binding protein |
| Protein Family: | Ras GTPase-activating protein |
| UniProt Gene Name: | RASA3Â Â |
| UniProt Entry Name: | RASA3_HUMAN |
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