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RASA3 Antibody (PACO11729)

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SKU:
PACO11729
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$551

Description

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RASA3 Antibody (PACO11729)

The RASA3 Antibody (PAC011729) is a valuable tool for researchers studying RASA3, a protein involved in regulating cellular signaling pathways. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the RASA3 protein, this antibody allows for the detection and analysis of RASA3 activity in various cell types.RASA3 is known for its role in modulating intracellular signaling cascades, particularly those involved in cell growth, differentiation, and survival.

Understanding the function of RASA3 is important for unraveling its impact on cellular processes and its potential implications in diseases such as cancer, cardiovascular disorders, and neurological conditions. By studying the activity of RASA3, researchers can gain insights into the mechanisms underlying these diseases and may identify new therapeutic targets for intervention.

Antibody Name:RASA3 Antibody (PACO11729)
Antibody SKU:PACO11729
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human RASA3
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:RAS p21 protein activator 3;RASA3;GAP1IP4BP;GAPIII;MGC46517;MGC47588 ;
UniProt Protein Function:RASA3: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.
UniProt Protein Details:

Protein type:GAPs; GAPs, Ras

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cytoplasm; cytosol

Molecular Function:calcium-release channel activity

Biological Process: MAPKKK cascade; negative regulation of Ras protein signal transduction; signal transduction

NCBI Summary:This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Code:Q14644
NCBI GenInfo Identifier:206729910
NCBI Gene ID:22821
NCBI Accession:Q14644.3
UniProt Secondary Accession:Q14644,Q8IUY2, A6NL15, F8W6X8,
UniProt Related Accession:Q14644
Molecular Weight:92,228 Da
NCBI Full Name:Ras GTPase-activating protein 3
NCBI Synonym Full Names:RAS p21 protein activator 3
NCBI Official Symbol:RASA3  
NCBI Official Synonym Symbols:GAPIII; GAP1IP4BP  
NCBI Protein Information:ras GTPase-activating protein 3
UniProt Protein Name:Ras GTPase-activating protein 3
UniProt Synonym Protein Names:GAP1(IP4BP); Ins P4-binding protein
Protein Family:Ras GTPase-activating protein
UniProt Gene Name:RASA3  
UniProt Entry Name:RASA3_HUMAN

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