The Ras Rabbit Monoclonal Antibody (CAB4735) is a valuable tool for researchers studying Ras, a family of small GTPases involved in cell signaling pathways regulating cell growth, differentiation, and survival. This antibody, produced using rabbit monoclonal technology, is highly specific for Ras and is validated for use in various applications, including Western blot and immunohistochemistry.Ras proteins are key players in oncogenic signaling, making them a hot topic in cancer research. The Ras Rabbit Monoclonal Antibody enables precise detection and analysis of Ras expression in cell lines and tissue samples, providing valuable insights into the role of Ras in cancer development and progression.
Furthermore, Ras is also implicated in other diseases, such as cardiovascular disorders and neurodevelopmental disorders. By using the Ras Rabbit Monoclonal Antibody, researchers can gain a better understanding of Ras function in these contexts, paving the way for potential therapeutic interventions targeting Ras signaling pathways.
Product Name:
NRAS Rabbit Monoclonal Antibody
SKU:
CAB4735
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NRAS (P01111).
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Purification Method:
Affinity purification
Gene ID:
4893/3265/3845
Clone Number:
ARC1112
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using KRAS+HRAS+NRAS Rabbit mAb (CAB4735) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
