The RARS2 Polyclonal Antibody (CAB8503) is a valuable tool for research involving RARS2, a mitochondrial aminoacyl-tRNA synthetase enzyme linked to various mitochondrial diseases. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the RARS2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in mitochondrial biology and genetic disorders.RARS2 plays a crucial role in mitochondrial protein synthesis and energy metabolism, making it essential for cellular function.
Mutations in the RARS2 gene have been associated with disorders such as pontocerebellar hypoplasia and mitochondrial encephalomyopathy, highlighting the importance of research on this enzyme for understanding and potentially treating these devastating conditions. The RARS2 Polyclonal Antibody offers researchers a reliable tool for investigating the function and dysregulation of RARS2 in disease states, ultimately aiding in the development of targeted therapeutic strategies.
Product Name:
RARS2 Rabbit Polyclonal Antibody
SKU:
CAB8503
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 17-340 of human RARS2 (NP_064716.2).
This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
57038
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RARS2 antibody (CAB8503) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
