The RARG Polyclonal Antibody (CAB7448) is a valuable tool for researchers studying the retinoic acid receptor gamma (RARG) protein, which belongs to the nuclear hormone receptor superfamily. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.RARG is known to play a key role in various biological processes, including cell differentiation, proliferation, and apoptosis. Dysregulation of RARG has been implicated in various diseases, including cancer and developmental disorders.
By targeting the RARG protein, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.This polyclonal antibody enables the specific detection and analysis of RARG in different cell types, making it ideal for studies in molecular biology, pharmacology, and drug discovery. Its high reactivity and specificity ensure reliable and consistent results, making it a valuable asset for any research project focused on understanding the role of RARG in health and disease.
Product Name:
RARG Rabbit Polyclonal Antibody
SKU:
CAB7448
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 168-199 of human RARG (NP_000957.1).
Sequence:
KKEV KEEG SPDS YELS PQLE ELIT KVSK AHQE
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
RARC; NR1B3; RARgamma; RARG
Positive Sample:
Mouse lung,Rat kidney
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
50kDa
Observed MW:
55kDa
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RARG antibody (CAB7448) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
