The Retinoic Acid Receptor Beta Rabbit Monoclonal Antibody (CAB4535) is a valuable tool for researchers studying retinoic acid receptor beta (RARβ), a nuclear receptor involved in the regulation of gene expression. This antibody, raised in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in various experimental techniques such as Western blotting.RARβ is known to play a critical role in cell differentiation, proliferation, and apoptosis, making it a key player in various biological processes including embryonic development, immune response, and carcinogenesis. The ability to specifically target and detect RARβ using this antibody allows for more detailed investigations into its function and potential therapeutic applications in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes.
By utilizing the Retinoic Acid Receptor Beta Rabbit Monoclonal Antibody (CAB4535), researchers can gain valuable insights into the molecular mechanisms underlying RARβ-mediated pathways, leading to a better understanding of its role in health and disease. This antibody is a valuable tool for studies in molecular biology, pharmacology, and drug discovery, providing crucial information for the development of targeted treatments and interventions in various medical fields.
Product Name:
RARβ Rabbit Monoclonal Antibody
SKU:
CAB4535
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-455 of human RARβ (NP_000956.2).
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5915
Clone Number:
ARC1024
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using RARβ Rabbit mAb (CAB4535) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
