The RARA Polyclonal Antibody (CAB0370) is a valuable tool for researchers studying the retinoic acid receptor alpha (RARA) protein, which plays a crucial role in various biological processes, including cell differentiation and proliferation. This rabbit-derived antibody is highly specific to human RARA samples and has been validated for use in Western blot applications.The RARA protein is a transcription factor that regulates gene expression in response to retinoic acid, a derivative of vitamin A. Dysregulation of RARA has been linked to several diseases, including certain types of cancer and developmental disorders.
By binding to the RARA protein, this antibody allows for precise detection and analysis of RARA levels in different cell types, making it an essential tool for studies in cancer biology, developmental biology, and pharmacology.Understanding the role of RARA in cellular processes and disease pathology is critical for the development of targeted therapies and diagnostic tools. This antibody provides researchers with a reliable means of investigating the function and expression of RARA in various experimental settings, ultimately advancing our knowledge of its involvement in health and disease.
Product Name:
RARα Rabbit Polyclonal Antibody
SKU:
CAB0370
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-457 of human RARα (NP_001019980.1).
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
Purification Method:
Affinity purification
Gene ID:
5914
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RARα Rabbit pAb (CAB0370) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
