The RAPSN Polyclonal Antibody (CAB6716) is a valuable tool for researchers studying the Receptor-Associated Protein Synapse-Associated Protein (RAPSN), a key protein involved in the clustering of acetylcholine receptors at the neuromuscular junction. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the RAPSN protein, this antibody allows for the identification and analysis of RAPSN in various cell types, making it ideal for studies in neurobiology and neuromuscular diseases.RAPSN is essential for proper neuromuscular transmission and muscle function, making it a crucial target for research into conditions such as myasthenia gravis and congenital myasthenic syndromes.
Understanding the role of RAPSN in the neuromuscular junction is paramount for developing effective treatments for these debilitating conditions. The RAPSN Polyclonal Antibody provides researchers with a reliable tool for investigating the function of RAPSN and its involvement in neuromuscular disorders, ultimately advancing our understanding of neuromuscular biology and potential therapeutic targets.
Product Name:
RAPSN Rabbit Polyclonal Antibody
SKU:
CAB6716
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human RAPSN (NP_116034.2).
This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
5913
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using RAPSN Rabbit pAb (CAB6716) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
