The Rapgef6 Polyclonal Antibody (CAB17161) is a valuable tool for researchers studying Rapgef6, a protein involved in intracellular signaling pathways related to cell growth and development. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the Rapgef6 protein, this antibody enables the detection and analysis of Rapgef6 expression in various cell types, making it ideal for investigations into cell signaling, cancer biology, and developmental biology.Rapgef6, also known as Epac2, is a guanine nucleotide exchange factor that plays a crucial role in the regulation of cAMP signaling pathways, which are implicated in diverse cellular processes such as cell proliferation, differentiation, and survival.
Dysregulation of Rapgef6 has been linked to various diseases, including cancer, neurological disorders, and cardiovascular diseases, highlighting its importance as a potential therapeutic target. Research on Rapgef6 is essential for understanding its role in cellular physiology and for developing targeted treatments for diseases associated with its dysfunction.
Product Name:
RAPGEF6 Rabbit Polyclonal Antibody
SKU:
CAB17161
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 145-240 of human RAPGEF6 (NP_001157858).
Enables several functions, including GTP-dependent protein binding activity; guanyl-nucleotide exchange factor activity; and phosphatidic acid binding activity. Involved in microvillus assembly; positive regulation of GTPase activity; and protein localization to plasma membrane. Located in several cellular components, including apical plasma membrane; centrosome; and endocytic vesicle.
Purification Method:
Affinity purification
Gene ID:
51735
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RAPGEF6 Rabbit pAb (CAB17161) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
