RAPGEF5 Antibody (PACO38086)
- SKU:
- PACO38086
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
RAPGEF5 Antibody (PACO38086)
The Rapgef5 Polyclonal Antibody (PACO38086) is a valuable tool for researchers studying Rapgef5, a protein involved in cell signaling pathways related to cell growth and differentiation. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Rapgef5 protein, this antibody enables the detection and analysis of Rapgef5 in a variety of cell types, making it an ideal choice for studies in cell biology and cancer research.Rapgef5 is a guanine nucleotide exchange factor that plays a crucial role in the regulation of Ras signaling, a pathway involved in cell proliferation and differentiation.
Dysregulation of Rapgef5 expression has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions. By studying the role of Rapgef5 in cell signaling pathways, researchers can gain valuable insights into the mechanisms underlying disease development and potentially identify new therapeutic targets for treatment.
| Antibody Name: | RAPGEF5 Antibody (PACO38086) |
| Antibody SKU: | PACO38086 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Rap guanine nucleotide exchange factor 5 protein (201-444AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO38086 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO38086 at dilution of 1:100. |
| Background: | Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. |
| Synonyms: | Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac), RAPGEF5, GFR KIAA0277 MRGEF |
| UniProt Protein Function: | RAPGEF5: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 7p15.3 Cellular Component: nucleus Molecular Function:GTP-dependent protein binding; Rap guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity |
| NCBI Summary: | Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q92565 |
| NCBI GenInfo Identifier: | 32171396 |
| NCBI Gene ID: | 9771 |
| NCBI Accession: | Q92565.1 |
| UniProt Secondary Accession: | Q92565,Q8IXU5, A4D140, |
| UniProt Related Accession: | Q92565 |
| Molecular Weight: | 52,083 Da |
| NCBI Full Name: | Rap guanine nucleotide exchange factor 5 |
| NCBI Synonym Full Names: | Rap guanine nucleotide exchange factor 5 |
| NCBI Official Symbol: | RAPGEF5Â Â |
| NCBI Official Synonym Symbols: | GFR; REPAC; MR-GEFÂ Â |
| NCBI Protein Information: | rap guanine nucleotide exchange factor 5 |
| UniProt Protein Name: | Rap guanine nucleotide exchange factor 5 |
| UniProt Synonym Protein Names: | Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF; Related to Epac; Repac |
| Protein Family: | Rap guanine nucleotide exchange factor |
| UniProt Gene Name: | RAPGEF5Â Â |
| UniProt Entry Name: | RPGF5_HUMAN |
Related Products
RAPGEF5 Antibody (PACO22545)
RAPGEF5 Antibody (PACO11722)
RAPGEF5 Antibody (PACO05815)
