RAPGEF5 Antibody (PACO22545)
- SKU:
- PACO22545
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
RAPGEF5 Antibody (PACO22545)
The RapGEF5 Antibody (PACO22545) is a valuable tool for researchers studying the RapGEF5 protein, a guanine nucleotide exchange factor involved in regulating cell signaling pathways. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By targeting the RapGEF5 protein, this antibody enables precise detection and analysis in a variety of cell types, allowing for in-depth investigation into its role in cellular processes.RapGEF5 is a key player in intracellular signaling cascades, particularly in pathways that regulate cell growth, differentiation, and survival.
Research on RapGEF5 is essential for understanding its function in various physiological and pathological conditions. By unraveling the mechanisms by which RapGEF5 influences cellular behavior, researchers can gain insights into its potential implications in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases.Overall, the RapGEF5 Antibody (PACO22545) provides researchers with a valuable tool for exploring the intricate functions of the RapGEF5 protein in different biological contexts, paving the way for advancements in drug development and therapeutic interventions.
| Antibody Name: | RAPGEF5 Antibody (PACO22545) |
| Antibody SKU: | PACO22545 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human RAPGEF5. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from RAW264.7 cells, using RAPGEF5 antibody. |
| Background: | Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. |
| Synonyms: | GFR; guanine nucleotide exchange factor for Rap1; M-Ras-regulated GEF; M-Ras-regulated Rap GEF; MR-GEF |
| UniProt Protein Function: | RAPGEF5: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 7p15.3 Cellular Component: nucleus Molecular Function:GTP-dependent protein binding; Rap guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity |
| NCBI Summary: | Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q92565 |
| NCBI GenInfo Identifier: | 32171396 |
| NCBI Gene ID: | 9771 |
| NCBI Accession: | Q92565.1 |
| UniProt Secondary Accession: | Q92565,Q8IXU5, A4D140, |
| UniProt Related Accession: | Q92565 |
| Molecular Weight: | 52,083 Da |
| NCBI Full Name: | Rap guanine nucleotide exchange factor 5 |
| NCBI Synonym Full Names: | Rap guanine nucleotide exchange factor 5 |
| NCBI Official Symbol: | RAPGEF5Â Â |
| NCBI Official Synonym Symbols: | GFR; REPAC; MR-GEFÂ Â |
| NCBI Protein Information: | rap guanine nucleotide exchange factor 5 |
| UniProt Protein Name: | Rap guanine nucleotide exchange factor 5 |
| UniProt Synonym Protein Names: | Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF; Related to Epac; Repac |
| Protein Family: | Rap guanine nucleotide exchange factor |
| UniProt Gene Name: | RAPGEF5Â Â |
| UniProt Entry Name: | RPGF5_HUMAN |
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