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RAPGEF5 Antibody (PACO11722)

SKU:
PACO11722
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$551

Description

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RAPGEF5 Antibody (PACO11722)

The RAPGEF5 Polyclonal Antibody (PAC011722) is a vital tool for researchers studying RAPGEF5, a protein involved in cellular signaling pathways and regulation of gene expression. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By targeting the RAPGEF5 protein, researchers can effectively study its function and role in various cell types, particularly in the fields of cell signaling and gene regulation.RAPGEF5, also known as Epac1, is a guanine nucleotide exchange factor that plays a crucial role in intracellular signaling cascades, particularly those involving cAMP. Its involvement in cellular processes such as cell proliferation, differentiation, and migration makes it a valuable target for research in cancer biology, neuroscience, and cardiovascular disease.

Understanding the function of RAPGEF5 can provide insights into potential therapeutic strategies for diseases associated with dysregulated cellular signaling pathways.Overall, the RAPGEF5 Polyclonal Antibody is a powerful tool for researchers seeking to delve deeper into the functions and mechanisms of RAPGEF5 in various cellular processes. Its high specificity and reactivity make it a valuable asset in the study of signaling pathways and gene regulation, offering new avenues for understanding and potentially targeting RAPGEF5 in disease settings.

Antibody Name:RAPGEF5 Antibody (PACO11722)
Antibody SKU:PACO11722
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human RAPGEF5
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:Rap guanine nucleotide exchange factor (GEF) 5;RAPGEF5;GFR;KIAA0277;MR-GEF;REPAC ;
UniProt Protein Function:RAPGEF5: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:GAPs; GAPs, Ras

Chromosomal Location of Human Ortholog: 7p15.3

Cellular Component: nucleus

Molecular Function:GTP-dependent protein binding; Rap guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity

NCBI Summary:Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
UniProt Code:Q92565
NCBI GenInfo Identifier:32171396
NCBI Gene ID:9771
NCBI Accession:Q92565.1
UniProt Secondary Accession:Q92565,Q8IXU5, A4D140,
UniProt Related Accession:Q92565
Molecular Weight:52,083 Da
NCBI Full Name:Rap guanine nucleotide exchange factor 5
NCBI Synonym Full Names:Rap guanine nucleotide exchange factor 5
NCBI Official Symbol:RAPGEF5  
NCBI Official Synonym Symbols:GFR; REPAC; MR-GEF  
NCBI Protein Information:rap guanine nucleotide exchange factor 5
UniProt Protein Name:Rap guanine nucleotide exchange factor 5
UniProt Synonym Protein Names:Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF; Related to Epac; Repac
Protein Family:Rap guanine nucleotide exchange factor
UniProt Gene Name:RAPGEF5  
UniProt Entry Name:RPGF5_HUMAN

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