RAPGEF5 Antibody (PACO05815)
- SKU:
- PACO05815
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
RAPGEF5 Antibody (PACO05815)
The RapGEF5 Polyclonal Antibody (PACO5815) is a valuable tool for research involving RapGEF5, a guanine nucleotide exchange factor implicated in various cellular processes, particularly in signaling pathways related to cell proliferation and migration. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the RapGEF5 protein, this antibody enables the detection and analysis of RapGEF5 expression in different cell types, making it an ideal choice for studies in cell biology and cancer research.RapGEF5 is known to play a critical role in regulating the activation of Rap1, a small GTPase involved in cell adhesion, migration, and cytoskeletal organization.
Dysregulation of RapGEF5 signaling has been associated with various diseases, including cancer, cardiovascular disorders, and neurological conditions. Therefore, investigating the function of RapGEF5 is crucial for understanding the underlying mechanisms of these diseases and potentially identifying new therapeutic targets.Overall, the RapGEF5 Polyclonal Antibody (PACO5815) offers researchers a reliable tool for studying the role of RapGEF5 in cellular pathways relevant to human health and disease. Its specificity and sensitivity make it a valuable asset for furthering our understanding of the molecular mechanisms governing cell signaling processes and identifying potential targets for therapeutic intervention.
| Antibody Name: | RAPGEF5 Antibody (PACO05815) |
| Antibody SKU: | PACO05815 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the Internal region of human Repac. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | RAPGEF5; GFR; KIAA0277; MRGEF; Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF; Related to Epac; Repac |
| UniProt Protein Function: | RAPGEF5: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 7p15.3 Cellular Component: nucleus Molecular Function:GTP-dependent protein binding; Rap guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity |
| NCBI Summary: | Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q92565 |
| NCBI GenInfo Identifier: | 32171396 |
| NCBI Gene ID: | 9771 |
| NCBI Accession: | Q92565.1 |
| UniProt Secondary Accession: | Q92565,Q8IXU5, A4D140, |
| UniProt Related Accession: | Q92565 |
| Molecular Weight: | 52,083 Da |
| NCBI Full Name: | Rap guanine nucleotide exchange factor 5 |
| NCBI Synonym Full Names: | Rap guanine nucleotide exchange factor 5 |
| NCBI Official Symbol: | RAPGEF5Â Â |
| NCBI Official Synonym Symbols: | GFR; REPAC; MR-GEFÂ Â |
| NCBI Protein Information: | rap guanine nucleotide exchange factor 5 |
| UniProt Protein Name: | Rap guanine nucleotide exchange factor 5 |
| UniProt Synonym Protein Names: | Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF; Related to Epac; Repac |
| Protein Family: | Rap guanine nucleotide exchange factor |
| UniProt Gene Name: | RAPGEF5Â Â |
| UniProt Entry Name: | RPGF5_HUMAN |
Related Products
RAPGEF5 Antibody (PACO22545)
RAPGEF5 Antibody (PACO11722)
RAPGEF5 Antibody (PACO38086)
HNRRabbit Polyclonal Antibody Rabbit Polyclonal Antibody (CAB17497)
