The RAPGEF1 Polyclonal Antibody (CAB16050) is a specialized tool for researchers studying the RAPGEF1 protein, a key player in cell signaling pathways. This antibody, developed using rabbit immunization, has high specificity for RAPGEF1 in human samples and has been validated for use in Western blot applications. By binding specifically to the RAPGEF1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for studies in cell signaling, molecular biology, and drug development.RAPGEF1, also known as Rap guanine nucleotide exchange factor 1, is involved in regulating cellular processes such as cell growth, differentiation, and migration through its role in activating small GTPases.
Dysregulation of RAPGEF1 has been linked to various diseases including cancer, cardiovascular disorders, and neurological conditions. By investigating the function and activity of RAPGEF1, researchers can gain insights into disease mechanisms and potentially identify new therapeutic targets for intervention.Overall, the RAPGEF1 Polyclonal Antibody (CAB16050) provides a valuable tool for studying the functions of RAPGEF1 in physiological and pathological conditions, offering researchers the opportunity to unravel complex signaling networks and develop targeted therapies for a range of diseases.
Product Name:
RAPGEF1 Rabbit Polyclonal Antibody
SKU:
CAB16050
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 844-1095 of human RAPGEF1 (NP_941372.1).
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
2889
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using RAPGEF1 Rabbit pAb (CAB16050) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
