The RANGAP1 Rabbit Monoclonal Antibody (CAB8758) is designed for research involving RANGAP1, a protein involved in the regulation of cell division and nuclear envelope assembly. The antibody, generated in rabbits, is highly specific and validated for use in immunofluorescence and immunohistochemistry applications. It binds specifically to the RANGAP1 protein, allowing for precise detection and analysis in various cell types.RANGAP1 plays a crucial role in the process of cell division, specifically in the regulation of the breakdown of the nuclear membrane during mitosis.
Its function is essential for the proper segregation of chromosomes and the formation of daughter cells. Dysregulation of RANGAP1 has been implicated in various diseases, including cancer and developmental disorders.By utilizing the RANGAP1 Rabbit Monoclonal Antibody, researchers can further explore the mechanisms underlying cell division and nuclear envelope dynamics. Understanding the role of RANGAP1 in disease pathology may lead to the development of targeted therapies aimed at modulating its activity for therapeutic benefit.
Product Name:
RanGAP1 Rabbit Monoclonal Antibody
SKU:
CAB8758
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RanGAP1 (P46060).
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5905
Clone Number:
ARC1292
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using RanGAP1 Rabbit mAb (CAB8758) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
