RANGAP1 Polyclonal Antibody (CAB13347) is a vital tool for researchers studying RANGAP1, a key protein involved in the regulation of cell division and nuclear envelope assembly. This antibody, produced in rabbits, has high specificity and sensitivity for detecting RANGAP1 in human samples, making it ideal for use in Western blot applications.RANGAP1 is essential for the proper localization of the RanGTPase on the nuclear envelope during mitosis, facilitating the regulation of nuclear transport and ensuring the fidelity of cell division.
Dysfunction of RANGAP1 has been implicated in various diseases, including cancer and neurodevelopmental disorders, making it a promising target for therapeutic interventions.With its ability to specifically bind to RANGAP1, this polyclonal antibody enables researchers to investigate the role of RANGAP1 in various cellular processes and disease states, advancing our understanding of its biological functions and potential implications for human health.
Product Name:
RanGAP1 Rabbit Polyclonal Antibody
SKU:
CAB13347
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 398-587 of human RanGAP1 (NP_002874.1).
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5905
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using RanGAP1 Rabbit pAb (CAB13347) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
