RANBP2 Rabbit Polyclonal Antibody (CAB18596)
- SKU:
- CAB18596
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | RANBP2 Rabbit Polyclonal Antibody |
SKU: | CAB18596 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2900-3050 of human RANBP2 (NP_006258.3). |
Sequence: | SDEE VVHN EDIH FEPI VSLP EVEV KSGE EDEE ILFK ERAK LYRW DRDV SQWK ERGV GDIK ILWH TMKN YYRI LMRR DQVF KVCA NHVI TKTM ELKP LNVS NNAL VWTA SDYA DGEA KVEQ LAVR FKTK EVAD CFKK TFEE CQQN LMKL QKG |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358; RANBP2 |
Cellular Localization: | cytoplasm, cytosol, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear pore, nuclear pore cytoplasmic filaments, nuclear pore nuclear basket, nucleoplasm |
Calculated MW: | 358kDa |
Observed MW: | Refer to figures |
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q.
Purification Method: | Affinity purification |
Gene ID: | 5903 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |