The RANBP17 Polyclonal Antibody (PAC022543) is a crucial tool for researchers studying RANBP17, a protein involved in nucleocytoplasmic transport and regulation of gene expression. This antibody, produced using rabbits as the host, exhibits high reactivity with human samples and is validated for use in immunohistochemistry and immunofluorescence applications. By binding specifically to the RANBP17 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in cell biology and gene regulation.RANBP17, also known as Ran-binding protein 17, plays a vital role in the transport of proteins and RNA molecules between the nucleus and cytoplasm, contributing to the regulation of essential cellular processes.
Its involvement in gene expression and protein localization makes it a promising target for research in areas such as developmental biology, cancer biology, and neurodegenerative diseases. By elucidating the functions of RANBP17, researchers can gain valuable insights into cellular mechanisms and potentially uncover new therapeutic targets for various disorders.
Antibody Name:
RANBP17 Antibody (PACO22543)
Antibody SKU:
PACO22543
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from N-terminal of human RANBP17.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells, using RANBP17 antibody.
Background:
May function as a nuclear transport receptor By similarity.
Synonyms:
Ran-binding protein 17; RANBP17;
UniProt Protein Function:
RANBP17: May function as a nuclear transport receptor. Belongs to the exportin family.Protein type: Nuclear export; Nuclear importChromosomal Location of Human Ortholog: 5q34Cellular Component: cytoplasm; nuclear poreMolecular Function: nuclear export signal receptor activity; Ran GTPase bindingBiological Process: protein export from nucleus
UniProt Protein Details:
NCBI Summary:
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
