The RAMP2 Polyclonal Antibody (CAB3075) is a valuable tool for researchers studying the receptor activity-modifying protein 2 (RAMP2) in various biological contexts. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to RAMP2, this antibody facilitates the detection and analysis of RAMP2 protein in different cell types, making it ideal for studies in cardiovascular biology, neurobiology, and endocrinology.RAMP2 is known for its role in modulating the activity of G-protein coupled receptors (GPCRs), which play crucial roles in signal transduction pathways. By interacting with GPCRs, RAMP2 contributes to the regulation of cardiovascular function, neurotransmission, and hormone secretion.
Understanding the function of RAMP2 is essential for uncovering the mechanisms underlying various physiological processes and diseases, including hypertension, neurological disorders, and hormonal imbalances.Overall, the RAMP2 Polyclonal Antibody is a highly specific and reliable tool for researchers aiming to investigate the role of RAMP2 in health and disease. Its versatility and effectiveness in Western blot applications make it an indispensable asset for studies aiming to unravel the complex signaling pathways regulated by RAMP2.
Product Name:
RAMP2 Rabbit Polyclonal Antibody
SKU:
CAB3075
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human RAMP2 (NP_005845.2).
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
Purification Method:
Affinity purification
Gene ID:
10266
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using RAMP2 Rabbit pAb (CAB3075) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
