[KO Validated] RAG2 Rabbit Polyclonal Antibody (CAB5626)
- SKU:
- CAB5626
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | [KO Validated] RAG2 Rabbit Polyclonal Antibody |
SKU: | CAB5626 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 351-527 of human RAG2 (NP_000527.2). |
Sequence: | AEDD TNEE QTTF TNSQ TSTE DPGD STPF EDSE EFCF SAEA NSFD GDDE FDTY NEDD EEDE SETG YWIT CCPT CDVD INTW VPFY STEL NKPA MIYC SHGD GHWV HAQC MDLA ERTL IHLS AGSN KYYC NEHV EIAR ALHT PQRV LPLK KPPM KSLR KKGS GKIL TPAK KSFL RRLF D |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | RAG-2; G2 |
Positive Sample: | Raji,Jurkat,293T,HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 59kDa |
Observed MW: | 59kDa |
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Purification Method: | Affinity purification |
Gene ID: | 5897 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |