RAG2 Rabbit Polyclonal Antibody (CAB12488)
- SKU:
- CAB12488
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | RAG2 Rabbit Polyclonal Antibody |
SKU: | CAB12488 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 258-527 of human RAG2 (NP_001230715.1). |
Sequence: | VSSA ILTQ TNND EFVI VGGY QLEN QKRM ICNI ISLE DNKI EIRE METP DWTP DIKH SKIW FGSN MGNG TVFL GIPG DNKQ VVSE GFYF YMLK CAED DTNE EQTT FTNS QTST EDPG DSTP FEDS EEFC FSAE ANSF DGDD EFDT YNED DEED ESET GYWI TCCP TCDV DINT WVPF YSTE LNKP AMIY CSHG DGHW VHAQ CMDL AERT LIHL SAGS NKYY CNEH VEIA RALH TPQR VLPL KKPP MKSL RKKG SGKI LTPA KKSF LRRL FD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | RAG-2; RAG2 |
Positive Sample: | Mouse testis,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 59kDa |
Observed MW: | 59kDa |
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Purification Method: | Affinity purification |
Gene ID: | 5897 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |