The RAD9B Polyclonal Antibody (PACO57212) is a valuable tool for researchers studying RAD9B, a gene involved in DNA damage response and cell cycle regulation. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blotting applications. By binding to the RAD9B protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in the fields of genomics and cancer research.RAD9B is an essential component of the DNA damage checkpoint pathway, where it plays a crucial role in sensing and repairing DNA damage to maintain genomic stability.
Dysregulation of RAD9B has been linked to genomic instability and cancer development, underscoring its importance in understanding disease mechanisms. Research on RAD9B can provide insights into potential therapeutic strategies targeting DNA repair pathways in cancer and other genetic disorders.By utilizing the RAD9B Polyclonal Antibody (PACO57212), researchers can gain valuable information about the function and regulation of RAD9B in various cellular processes, ultimately contributing to advancements in the fields of DNA repair, cancer biology, and personalized medicine.
Antibody Name:
RAD9B Antibody (PACO57212)
Antibody SKU:
PACO57212
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant Human Cell cycle checkpoint control protein RAD9B protein (274-408AA)
Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: RAD9B antibody at 6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 48, 47, 39, 29, 30 kDa. Observed band size: 48 kDa.
Background:
checkpoint clamp complex, nucleoplasm, 3'-5' exonuclease activity, cellular response to ionizing radiation, DNA repair, DNA replication, DNA replication checkpoint, intra-S DNA damage checkpoint, nucleic acid, phosphodiester bond hydrolysis, regulation of signal transduction by p53 class mediator
Synonyms:
Cell cycle checkpoint control protein RAD9B (DNA repair exonuclease rad9 homolog B) (hRAD9B), RAD9B
UniProt Protein Function:
RAD9B: Belongs to the rad9 family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: DNA replicationChromosomal Location of Human Ortholog: 12q24.11Cellular Component: nucleoplasmMolecular Function: 3'-5' exonuclease activity; protein bindingBiological Process: DNA repair; DNA replication; DNA replication checkpoint; intra-S DNA damage checkpoint
