The RAD9A Polyclonal Antibody (PACO04862) is a vital tool for researchers studying RAD9A, a protein involved in DNA damage response and repair pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards RAD9A in human samples, making it ideal for Western blot applications.RAD9A plays a crucial role in maintaining genomic stability and preventing the accumulation of DNA damage, thereby protecting cells from mutations and tumorigenesis. Dysregulation of RAD9A has been linked to various cancers and genetic disorders, highlighting its importance in cellular integrity and function.
By utilizing the RAD9A Polyclonal Antibody, researchers can accurately detect and analyze RAD9A expression in different cell types, advancing our understanding of its functions in DNA repair mechanisms. This antibody is essential for investigations in cancer biology, genomics, and therapeutics aimed at targeting DNA damage response pathways for innovative treatment strategies.
Antibody Name:
RAD9A Antibody
Antibody SKU:
PACO04862
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from human Rad9 around the non-phosphorylation site of S272.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
RAD9A; Cell cycle checkpoint control protein RAD9A; hRAD9; DNA repair exonuclease rad9 homolog A
UniProt Protein Function:
Rad9: a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. Possesses a 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. Forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for Rad9.Protein type: EC 3.1.11.2; DNA replication; Deoxyribonuclease; Apoptosis; Cell cycle regulationChromosomal Location of Human Ortholog: 11q13.1-q13.2Cellular Component: nucleoplasm; cytoplasm; nucleusMolecular Function: protein binding; enzyme binding; histone deacetylase binding; exodeoxyribonuclease III activity; 3'-5' exonuclease activity; SH3 domain binding; protein kinase bindingBiological Process: intra-S DNA damage checkpoint; DNA damage checkpoint; DNA replication checkpoint; DNA replication; DNA repair; DNA catabolic process, exonucleolytic; response to DNA damage stimulus
