The RAD51C Polyclonal Antibody (CAB12487) is specifically designed for research involving the RAD51C protein, a key player in DNA repair and homologous recombination. The antibody is raised in rabbits and is highly reactive with human samples, making it an ideal tool for studies in genetics and cancer research. RAD51C is essential for maintaining genomic stability and preventing the accumulation of DNA mutations that can lead to cancer development. By detecting and analyzing RAD51C protein levels in various cell types, researchers can gain valuable insights into the mechanisms of DNA repair and potential therapeutic targets for cancer treatment.
The RAD51C Polyclonal Antibody is validated for use in Western blot applications, allowing for precise and reliable detection of RAD51C protein in experimental samples. Its high specificity and sensitivity make it a valuable tool for investigating the role of RAD51C in DNA repair pathways and its potential implications for cancer biology.
Product Name:
RAD51C Rabbit Polyclonal Antibody
SKU:
CAB12487
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-135 of human RAD51C (NP_002867.1).
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5889
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of MCF7 cells using RAD51C antibody (CAB12487).
