The RAD51B Polyclonal Antibody (CAB6962) is a valuable tool for researchers studying RAD51B, a key protein involved in DNA repair processes. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the RAD51B protein, this antibody enables the detection and analysis of RAD51B levels in different cell types, making it ideal for research in genetics and cancer biology.RAD51B is a crucial player in homologous recombination, a DNA repair mechanism that maintains genomic stability and prevents the accumulation of mutations.
Dysregulation of RAD51B has been linked to various diseases, including cancer, where impaired DNA repair mechanisms can contribute to tumor progression. By understanding the function of RAD51B and its role in DNA repair, researchers can gain insights into disease mechanisms and potentially develop targeted therapies for cancer treatment.
Product Name:
RAD51B Rabbit Polyclonal Antibody
SKU:
CAB6962
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human RAD51B (NP_598193.2).
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata.
Purification Method:
Affinity purification
Gene ID:
5890
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RAD51B Rabbit pAb (CAB6962) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
