Rad51 Rabbit Polyclonal Antibody (CAB6268)
- SKU:
- CAB6268
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | Rad51 Rabbit Polyclonal Antibody |
SKU: | CAB6268 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human Rad51 (NP_002866.2). |
Sequence: | MAMQ MQLE ANAD TSVE EESF GPQP ISRL EQCG INAN DVKK LEEA GFHT VEAV AYAP KKEL INIK GISE AKAD KILA EAAK LVPM GFTT ATEF HQRR SEII QITT GSKE LDKL LQGG IETG SITE MFGE FRTG KTQI CHTL AVTC QLPI DRGG GEGK AMYI DTEG TFRP ERLL AVAE RYGL SGSD VLDN VAYA RAFN TDHQ TQLL YQAS AMMV ESRY ALLI VDSA TALY RTDY SGRG ELSA RQMH LARF LRML LRLA DEFG VAVV ITNQ VVAQ VDGA AMFA ADPK KPIG GNII AHAS TTRL YLRK GRGE TRIC KIYD SPCL PEAE AMFA INAD GVGD AKD |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | RECA; BRCC5; FANCR; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930; Rad51 |
Positive Sample: | Mouse kidney,C6,Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Mitochondrion matrix, Nucleus, centrosome, cytoskeleton, microtubule organizing center, perinuclear region. |
Calculated MW: | 37kDa |
Observed MW: | 37kDa |
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5888 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |