Rad50 Rabbit Polyclonal Antibody (CAB0182)
- SKU:
- CAB0182
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | Rad50 Rabbit Polyclonal Antibody |
SKU: | CAB0182 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-270 of human Rad50 (NP_005723.2). |
Sequence: | MSRI EKMS ILGV RSFG IEDK DKQI ITFF SPLT ILVG PNGA GKTT IIEC LKYI CTGD FPPG TKGN TFVH DPKV AQET DVRA QIRL QFRD VNGE LIAV QRSM VCTQ KSKK TEFK TLEG VITR TKHG EKVS LSSK CAEI DREM ISSL GVSK AVLN NVIF CHQE DSNW PLSE GKAL KQKF DEIF SATR YIKA LETL RQVR QTQG QKVK EYQM ELKY LKQY KEKA CEIR DQIT SKEA QLTS SKEI VKSY ENEL DPLK NRLK EIEH NLSK IMKL DN |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | NBSLD; RAD502; hRad50; Rad50 |
Positive Sample: | NIH3T3,MCF-7,A-549,HT-29,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, telomere. |
Calculated MW: | 154kDa |
Observed MW: | 180kDa |
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
Purification Method: | Affinity purification |
Gene ID: | 10111 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |