The RAD23B Polyclonal Antibody is a valuable tool for research involving RAD23B, a protein involved in DNA repair and protein degradation pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the RAD23B protein, this antibody enables researchers to detect and analyze RAD23B expression in various cell types, making it a valuable asset for studies in molecular biology and cancer research.RAD23B plays a critical role in maintaining genomic stability by facilitating the recognition and removal of damaged proteins and DNA lesions.
Dysregulation of RAD23B has been implicated in various diseases, including cancer and neurodegenerative disorders. Understanding the function of RAD23B is crucial for developing targeted therapies that exploit its role in DNA repair mechanisms.Overall, the RAD23B Polyclonal Antibody provides researchers with a powerful tool for investigating the role of RAD23B in cellular processes and disease development, paving the way for new insights and potential therapeutic strategies.
Product Name:
Rad23B Polyclonal Antibody
SKU:
CAB21586
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Rad23B (NP_002865.1).
Sequence:
TSST TTTV AQAP TPVP ALAP TSTP ASIT PASA TASS EPAP ASAA KQEK PAEK PAET PVAT SPTA TDST SGDS SRSN LFED ATSA LVTG QSYE NMVT EIMS M
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
5887
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Rad23B Rabbit pAb (CAB21586) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
