The RAD23A Polyclonal Antibody (CAB19884) is a valuable tool for researchers studying RAD23A, a key protein involved in DNA repair and proteasomal degradation. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to RAD23A, this antibody allows for the detection and analysis of this essential protein in various cell types, making it ideal for investigations in areas such as molecular biology and cancer research.RAD23A plays a crucial role in maintaining genome integrity by participating in the recognition and removal of damaged DNA, as well as facilitating the degradation of misfolded proteins.
Dysregulation of RAD23A has been associated with various diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular homeostasis. By studying RAD23A using this antibody, researchers can gain insights into its function and potential therapeutic targets for conditions involving DNA damage and protein quality control mechanisms.
Product Name:
[KO Validated] Rad23A Rabbit Polyclonal Antibody
SKU:
CAB19884
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-363 of human Rad23A (NP_005044.1).
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms.
Purification Method:
Affinity purification
Gene ID:
5886
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and Rad23A knockout (KO) 293T cells, using [KO Validated] Rad23A Rabbit pAb (CAB19884) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
