Rad18 Rabbit Polyclonal Antibody (CAB5380)
- SKU:
- CAB5380
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | Rad18 Rabbit Polyclonal Antibody |
SKU: | CAB5380 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 216-495 of human Rad18 (NP_064550.3). |
Sequence: | INKH LDSC LSRE EKKE SLRS SVHK RKPL PKTV YNLL SDRD LKKK LKEH GLSI QGNK QQLI KRHQ EFVH MYNA QCDA LHPK SAAE IVRE IENI EKTR MRLE ASKL NESV MVFT KDQT EKEI DEIH SKYR KKHK SEFQ LLVD QARK GYKK IAGM SQKT VTIT KEDE STEK LSSV CMGQ EDNM TSVT NHFS QSKL DSPE ELEP DREE DSSS CIDI QEVL SSSE SDSC NSSS SDII RDLL EEEE AWEA SHKN DLQD TEIS PRQN RRTR AAES AEIE PRNK RNRN |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | RNF73; Rad18 |
Positive Sample: | MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center. |
Calculated MW: | 56kDa |
Observed MW: | 80kDa |
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
Purification Method: | Affinity purification |
Gene ID: | 56852 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |