The RAC1/2/3 Polyclonal Antibody (CAB21786) is a valuable tool for researchers studying RAC1, RAC2, and RAC3, members of the Rho GTPase family known to regulate cytoskeletal dynamics and cell migration. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the RAC1, RAC2, and RAC3 proteins, enabling precise detection and analysis in various cell types.RAC1, RAC2, and RAC3 play crucial roles in cell signaling pathways that control processes such as cell adhesion, proliferation, and differentiation.
Dysregulation of these proteins has been implicated in various diseases, including cancer and neurological disorders. By utilizing the RAC1/2/3 Polyclonal Antibody, researchers can gain insights into the functions of these proteins and their potential as therapeutic targets in cancer and other conditions. This antibody is an essential tool for studies in cell biology, oncology, and drug development.
Product Name:
Rac1/2/3 Polyclonal Antibody
SKU:
CAB21786
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-192 of human Rac1/2/3 (NP_008839.2).
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5879
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from A-431 cells, using Rac1/2/3 Rabbit pAb (CAB21786) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
