What is Rabies Virus?

Rabies is caused by a neurotropic lyssavirus that, once symptomatic, is almost invariably fatal; the viral glycoprotein G is the target of neutralising antibodies.

It is transmitted through the saliva of infected animals, usually via bites, and is preventable with vaccination and post-exposure prophylaxis. Antibody assays and recombinant G antigen support seroconversion and vaccine studies.

Transmission & symptoms

Rabies is caused by a neurotropic lyssavirus transmitted in the saliva of infected animals, usually through bites. Once neurological symptoms appear it is almost universally fatal, but it is preventable by prompt vaccination and post-exposure prophylaxis.

Diagnosis & serology

Protection is defined by rabies-virus-neutralising antibody titres; the glycoprotein G is the neutralising target. ELISA and neutralisation assays measure seroconversion after vaccination.

Research applications

Research tools cover rabies neuro-entry (nicotinic acetylcholine receptor, NCAM/CD56, p75NTR/NGFR), the viral glycoprotein G and antibody responses relevant to vaccine and PEP research.