| UniProt Protein Function: | RABGEF1: Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. Interacts with RGS14; the interaction is GTP-dependent. Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GAP, Rab; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 7q11.21Cellular Component: early endosomeMolecular Function: protein binding; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activityBiological Process: protein targeting to membrane |
| UniProt Protein Details: | |
| NCBI Summary: | RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010] |
| UniProt Code: | Q9UJ41 |
| NCBI GenInfo Identifier: | 77176717 |
| NCBI Gene ID: | 27342 |
| NCBI Accession: | ABA64473.1 |
| UniProt Secondary Accession: | Q9UJ41,Q3HKR2, Q3HKR3, Q53FG0, B4DZM7 |
| UniProt Related Accession: | Q9UJ41 |
| Molecular Weight: | 58,526 Da |
| NCBI Full Name: | RAP1 |
| NCBI Synonym Full Names: | RAB guanine nucleotide exchange factor 1 |
| NCBI Official Symbol: | RABGEF1Â Â |
| NCBI Official Synonym Symbols: | RAP1; RABEX5; rabex-5Â Â |
| NCBI Protein Information: | rab5 GDP/GTP exchange factor |
| UniProt Protein Name: | Rab5 GDP/GTP exchange factor |
| UniProt Synonym Protein Names: | RAP1; Rabaptin-5-associated exchange factor for Rab5; Rabex-5 |
| Protein Family: | Rap1 GTPase-activating protein |
| UniProt Gene Name: | RABGEF1Â Â |
| UniProt Entry Name: | |
