RABEP1 Antibody (PACO62455)
- SKU:
- PACO62455
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
RABEP1 Antibody (PACO62455)
The RabEP1 Polyclonal Antibody (PAC062455) is a valuable tool for researchers studying RabEP1, a protein involved in intracellular membrane trafficking processes. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the RabEP1 protein, enabling precise detection and analysis in various cell types, making it well-suited for investigations in cell biology and molecular biology.RabEP1 is known to play a significant role in regulating the transport of molecules within cells, contributing to various cellular functions such as signal transduction and organelle organization.
By targeting RabEP1, researchers can gain insights into fundamental cellular processes and potentially uncover new therapeutic targets for diseases related to abnormal intracellular trafficking. The utility of the RabEP1 Polyclonal Antibody in these research areas highlights its importance in advancing our understanding of cellular dynamics and disease mechanisms.
| Antibody Name: | RABEP1 Antibody (PACO62455) |
| Antibody SKU: | PACO62455 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Rab GTPase-binding effector protein 1 protein (1-255AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, 293T whole cell lysate, SH-SY5Y whole cell lysate, HepG2 whole cell lysate, 293 whole cell lysate, A549 whole cell lysate. All lanes: RABEP1 antibody at 1:2500. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 100, 96 kDa. Observed band size: 100 kDa. |
 | IHC image of PACO62455 diluted at 1:300 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. |
| Synonyms: | Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17), RABEP1, RAB5EP RABPT5 RABPT5A |
| UniProt Protein Function: | RABEP1: Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Belongs to the rabaptin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: recycling endosome; intracellular membrane-bound organelle; endocytic vesicle; early endosome; endosome Molecular Function:protein binding; protein homodimerization activity; growth factor activity; GTPase activator activity Biological Process: vesicle-mediated transport; protein transport; apoptosis; endocytosis; positive regulation of GTPase activity |
| UniProt Code: | Q15276 |
| NCBI GenInfo Identifier: | 116242743 |
| NCBI Gene ID: | 9135 |
| NCBI Accession: | Q15276.2 |
| UniProt Secondary Accession: | Q15276,O95369, Q8IVX3, B2RAG7, |
| UniProt Related Accession: | Q15276 |
| Molecular Weight: | 862 |
| NCBI Full Name: | Rab GTPase-binding effector protein 1 |
| NCBI Synonym Full Names: | rabaptin, RAB GTPase binding effector protein 1 |
| NCBI Official Symbol: | RABEP1Â Â |
| NCBI Official Synonym Symbols: | RAB5EP; RABPT5Â Â |
| NCBI Protein Information: | rab GTPase-binding effector protein 1; rabaptin-4; rabaptin-5; neurocrescin; rabaptin-5alpha; renal carcinoma antigen NY-REN-17 |
| UniProt Protein Name: | Rab GTPase-binding effector protein 1 |
| UniProt Synonym Protein Names: | Rabaptin-4; Rabaptin-5; Rabaptin-5alpha; Renal carcinoma antigen NY-REN-17 |
| Protein Family: | Rab GTPase-binding effector protein |
| UniProt Gene Name: | RABEP1Â Â |
| UniProt Entry Name: | RABE1_HUMAN |
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