The Rab7a Polyclonal Antibody (CAB12784) is a valuable tool for researchers studying the Rab7a protein, a key regulator of endosomal trafficking and lysosome biogenesis. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in Western blot applications.Rab7a is a small GTPase protein that plays a crucial role in the endocytic pathway, controlling the transport of proteins and lipids within the cell. Dysregulation of Rab7a has been implicated in various diseases, including neurodegenerative disorders and cancer. By targeting Rab7a with this polyclonal antibody, researchers can accurately detect and analyze its expression levels in different cell types, advancing our understanding of its function in health and disease.
With its versatility and reliability, the Rab7a Polyclonal Antibody (CAB12784) is a valuable tool for studies in cell biology, neuroscience, and cancer research. By enabling precise detection of Rab7a protein, this antibody opens up opportunities for further investigation into the molecular mechanisms underlying endosomal trafficking and its impact on cellular homeostasis.
Product Name:
RAB7 Rabbit Polyclonal Antibody
SKU:
CAB12784
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-207 of human RAB7 (NP_004628.4).
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
Purification Method:
Affinity purification
Gene ID:
7879
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using RAB7 Rabbit pAb (CAB12784) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
