The Rab7 Rabbit Monoclonal Antibody is specifically designed for research involving Rab7, a small GTPase protein that plays a key role in regulating intracellular vesicular transport and endocytic trafficking. This antibody, generated using rabbit monoclonal technology, is highly specific and reactive with human samples, making it an essential tool for studying Rab7 in various cellular processes.Rab7 is known to be involved in the late endocytic pathway, lysosome biogenesis, and autophagy, making it a crucial player in cellular homeostasis and signaling. By targeting Rab7 with this antibody, researchers can effectively detect and analyze its expression and localization in different cell types, providing valuable insights into its function and potential therapeutic targets.
This Rab7 Rabbit Monoclonal Antibody is validated for use in Western blot applications, immunofluorescence, and immunohistochemistry, offering versatility and reliability for experimental studies in cell biology, molecular biology, and disease research. Its high specificity and sensitivity make it an excellent choice for investigating the roles of Rab7 in various physiological and pathological conditions.
Product Name:
RAB7 Rabbit Monoclonal Antibody
SKU:
CAB12308
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 108-207 of human RAB7 (NP_004628.4).
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
Purification Method:
Affinity purification
Gene ID:
7879
Clone Number:
ARC54437
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using RAB7 Rabbit mAb (CAB12308) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
