The Rab5c Polyclonal Antibody is a valuable tool for research focused on Rab5c, a small GTPase involved in regulating intracellular membrane trafficking and endocytosis. This antibody, raised in rabbits, exhibits high specificity and sensitivity when detecting Rab5c protein in human samples, making it ideal for use in Western blot applications.Rab5c is known to play a crucial role in the endocytic pathway, specifically in the early stages of endosome maturation. Dysregulation of Rab5c has been implicated in various diseases, including cancer and neurodegenerative disorders.
By targeting Rab5c with this polyclonal antibody, researchers can study its function and potential therapeutic implications in these pathological conditions.Furthermore, this antibody's reactivity with Rab5c protein in various cell types makes it a versatile tool for investigating the molecular mechanisms underlying membrane trafficking and intracellular signaling processes. Its application in cell biology and disease research makes it a valuable resource for scientists seeking to explore the role of Rab5c in health and disease.
Product Name:
RAB5C Polyclonal Antibody
SKU:
CAB21583
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-216 of human RAB5C (NP_958842.1).
Cell membrane, Cytoplasmic side, Early endosome membrane, Lipid-anchor, Melanosome.
Calculated MW:
23kDa
Observed MW:
23kDa
Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).
Purification Method:
Affinity purification
Gene ID:
5878
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from A549 cells using RAB5C Rabbit pAb(CAB21583) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
